Which is a better medicine for a fever, Flexon or Combiflam




Flexon and Combiflam Tablet are medicines, which are mostly used to treat fever, febrility, cold, joint pain, toothache, analgesic and other conditions. When the condition of fever arises, these medicines are highly recommended by physicians. But before knowing that which medicine is better, it is important to know that what is fever and what conditions can lead to it.  

What is Fever?

Fever (medically termed as Pyrexia) is a medical condition where the temperature of human body increases than normal. The temperature of a normal human body can vary from person to person. But on an average, the body temperature remains up to 98.6-degree Fahrenheit or 37-degree Celsius. The temperature above the normal range is known as fever.

Fever indicates that our body is trying to fight illness or any other infection. It is an indicative condition of inflammation in the body. Fever is mainly caused by external infection. When our body tries to kill any antigen (foreign substances that trigger the immune system of our body resulting in production of antibodies in the body to fight it), it increases the body temperature.

This is because at normal body temperature, it is easy for viruses or bacteria to survive within the body. However, when the body temperature arises, it becomes difficult for them to sustain life in the host.  So, fever is a way of human body to fight the foreign invasion of virus and bacteria.

Body temperature is determined by its thermoregulatory set-point. This is done by hypothalamus, which is a small part of brain serving as the command center of various body activities, including temperature regulation. When an antigen enters the body, the thermoregulatory set-point of the body increases, i.e. it increases its temperature. This condition is called hypothermia, where body perceives that it is cold and in response, it increases its temperature. When body increases the body temperature, common symptoms like cold, stiffness, shivering occur.

Causes of Fever

As mentioned above, fever can occur in human body due to the presence of multiple antigens in the body. Fever is not a disease by its own but is an indication that something is going wrong within our body. Rest than the presence of antigens, there could be multiple other reasons which could lead to fever. Some of those include:

  • Infections: Many infectious diseases like common cold, influenza, HIV, malaria, dengue can be the reason of fever.
  • Hemolysis: Any damage to the body tissues (like in condition where Red Blood Cells (RBCs) break to release haemoglobin) can also cause fever.
  • Side Effects of Drugs: Consuming legal or illegal drugs (like antibiotics, narcotics, barbiturates, cocaine and amphetamines) can be a cause of fever due to adverse reactions.
  • Childhood Immunization: Immunization can also lead to mild fever due to the action of vaccination.
  • Miscellaneous Reasons: Fever could also be caused due to multiple other reasons or medical conditions like inflammation, lupus, blood clots, metabolic disorder, arthritis, inflammatory bowel disease and more.

Types of Fever

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Fever can be classified according to its span, severity and other patterns. According to the span of affecting period, fever could be of the following three types:

  • Acute: This fever can last up to seven days. For example, viral fever usually lasts up to at least seven days.
  • Sub-acute: This type of fever can last up to at least 14 days, like in case of Typhoid.
  • Chronic: This type of fever is persistent and could last more than 14 days. For example, in case of HIV, TB or cancer.

According to the severity, fever could be classified as:

  • Low grade
  • Moderate
  • High
  • Hyperpyrexia

Based on multiple other patterns, fever would be classified as:

  • Remittent: Specifies the state in which your fever fluctuates by more than 2 degrees and does not come down to normal (e.g. Typhoid).
  • Intermittent: Specifies the state in which the fever shows up for several hours, but not all the time in a day (e.g. Tuberculosis).
  • Sustained: Specifies the state in which the fever does not fluctuate for more than 1.5-degree Fahrenheit over 24 hours and comes down to normal in between (e.g. infective endocarditis).
  • Fever of Undetermined Origin: Specifies the state in which the fever exists for several days or weeks with no explanation or finding.

Symptoms of Fever

Fever itself is a symptom, which indicates that something is going wrong within the body. Alongside the high body temperature, the patient suffering from fever may also observe one or more of the following symptoms:

  • Skin flushing
  • Weakness
  • Chills
  • Excessive sweating
  • Pain
  • Depression
  • Low appetite

Medication for Fever

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Depending upon the cause, type and severity of fever, a physician will prescribe you the medication. Medicines like Flexon and Combiflam are often prescribed by the physicians, as they are painkillers and anti- inflammatory drugs. Both medicines have similar composition, Brufen and Paracetamol. The major ingredients of those is paracetamol, which is antipyretic in nature.

  • Combiflam: It is used to treat fever, back pain and headache. It works by blocking the prostaglandin chemical produced by the human body during pain. Ibrufen in Combiflam is a nonsteroidal inflammatory drug, which is very effective in treating pain, inflammation and fever. This way, Combiflam is more effective in treating fever and its associated symptoms.
  • Flexon: It is an anti-inflammatory, analgesic and antipyretic medicine. It is used for fever, toothache, body pain, cephalalgia and other conditions. Flexon also works the same way as Combiflam, i.e. by blocking down the production of prostaglandin which is released during pain in the body. It also increases the pain threshold of body and increases the flow of blood across the blood vessels.

Side Effects of Combiflam and Flexon

There could be side effects of these medicines, depending upon the medical condition of the patient. Some of the side effects include:

  • Flexon:
    • Allergic reactions
    • Headache
    • Heartburn
    • Kidney problems
    • Itching
    • Abdominal pain
  • Combiflam:
    • Constipation
    • Skin rash
    • Eczema
    • Gas
    • High blood pressure
    • Swollen face


Both, Combiflam and Flexon, have their own contraindications, i.e. there are certain limitations to the usage of these medicines. Some of those include:

  • Gastro-intestinal Bleeding: Both the medicines are not recommended to the patients with peptic ulcer or any gastrointestinal disorder.
  • Asthma: Those are not prescribed for patients of asthma, urticarial, rhinitis and recent heart surgery.
  • Allergies: Patients who are allergic to non-steroidal anti-inflammatory are suggested not to take Combiflam.

Frequently Asked Question About Combiflam and Flexon

1- Which one of these is better, Combiflam or Flexon?

Composition of both medicines (i.e. brufen and paracetamol) is same. There is no difference in these apart from the availability. In Asian countries like India, Combiflam is one of the most popular pain reliever and could be easily found at any authorized drug store.

2- For what purposes these can be used?

Flexon and Combiflam are mainly used mainly for relieving the patient from fever and pain in the body. These can also be consumed for treating mild headache, toothache or back pain.

3- Can these medicines be taken on empty stomach?

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On an empty stomach, these can cause irritation on the stomach lining. Hence it is better to take these medicines with food or a glass of milk.

4- Why Combiflam is banned in some countries?

Batches of Combiflam are being withdrawn from the market because Indias drug regulatory found them of substandard.

5- Are these medicines addictive or habit forming?

No, these medicines dont come with a potential of addiction or abuse. However, do not self-medicate and ask your physician before increasing the dosage.

6- What are dosage instructions for these?

Missed dose can be taken whenever you recall but avoid if its time for the next dose. In case of overdose, you should seek medical treatment as soon as possible.

7- Are there any substitutes for these two medicines?

There are multiple medicines, which have similar composition and effect as Combiflam and Flexon. Some of those include Brufamol, Zupar, Ibupar, Lupiflam, Cincofen, Inflagesic plus, and Combinam.

8- Can these medicines be stopped immediately or needed to be slowly ween off?

It depends on your symptoms and severity for which you are consuming those. You need to consult your physician to specify the time by which you should stop or slowly lower the dose of these medicines.


Both medicines, Flexon and Combiflam, are composed of anti-inflammatory and antipyretic chemicals. Both are powerful and effective, reduce fever and relieve pain. These medicines do not cure the fever, which is not an illness, but a symptom of any other disease. These medicines are used just to maintain the temperature of the body.

To address the actual cause of fever, you must go through the medical examinations at the medical laboratories prescribed by a physician. Fever is a sign that your body is trying to handle something like viral or bacterial invasion from outside. Our body is self-taught in making antibodies against any antigen. Any of the two medicines (Combiflam or Flexon) hold equal significance in working against the symptoms of fever.